Common Variations in Perilipin rs1052700 and FTO rs3751812 Gene Variants, and Risk for Obesity and Type-2 Diabetes.

ABSTRACT: BACKGROUND:Perilipins are proteins that coat lipid globules in adipocytes, which are steroid-generating cells that play a central role in lipid storage and breakdown. The FTO gene is associated with type-2 diabetes (T2D) and increased fat mass. In this work the association of perilipin and FTO gene polymorphisms in T2D was investigated. METHODS:One hundred eighty-three Iranian men and women with T2D, and 174 healthy controls with no known metabolic diseases, participated in the study. The subjects were genotyped using tetra-primer amplification refractory mutation system-polymerase chain reaction (Tetra-ARMS-PCR) and their clinical traits were analyzed. RESULTS:A significant association was found between the perilipin rs1052700 polymorphism and T2D, and between the FTO rs3751812 polymorphi

SUBMITTER: Saravani R 

PROVIDER: S-EPMC5643444 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature