Encrypted Antimicrobial Peptides from Plant Proteins.

ABSTRACT: Examples of bioactive peptides derived from internal sequences of proteins are known for decades. The great majority of these findings appear to be fortuitous rather than the result of a deliberate and methodological-based enterprise. In the present work, we describe the identification and the biological activities of novel antimicrobial peptides unveiled as internal fragments of various plant proteins founded on our hypothesis-driven search strategy. All putative encrypted antimicrobial peptides were selected based upon their physicochemical properties that were iteratively selected by an in-house computer program named Kamal. The selected peptides were chemically synthesized and evaluated for their interaction with model membranes. Sixteen of these peptides showed antimicrobial activity

SUBMITTER: Ramada MHS 

PROVIDER: S-EPMC5643462 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature