Comparative study of topical vs. intravenous tranexamic acid regarding blood loss in total knee arthroplasty.

ABSTRACT:

Objective

To compare topical vs. intravenous tranexamic acid (TA) in total knee arthroplasty regarding blood loss and transfusion.

Methods

Ninety patients were randomized to receive TA intravenously (20 mg/kg in 100 mL of saline; group IV), topically (1.5 g in 50 mL of saline, sprayed over the operated site, before release of the tourniquet; topical group), or intravenous saline (100 mL with anesthesia; control group). The volume of drained blood in 48 h, the amount of transfused blood, and the serum levels of hemoglobin and hematocrit before and after surgery were evaluated.

Results

The groups were similar for gender, age, weight, laterality, and preoperative hemoglobin and hematocrit levels (p > 0.2). The hemoglobin level dropped in all groups when com

SUBMITTER: Zekcer A 

PROVIDER: S-EPMC5643894 | biostudies-literature | 2017 Sep-Oct

REPOSITORIES: biostudies-literature