Comparative genomic analyses highlight the contribution of pseudogenized protein-coding genes to human lincRNAs.

ABSTRACT:

Background

The regulatory roles of long intergenic noncoding RNAs (lincRNAs) in humans have been revealed through the use of advanced sequencing technology. Recently, three possible scenarios of lincRNA origins have been proposed: de novo origination from intergenic regions, duplication from other long noncoding RNAs, and pseudogenization from protein-coding genes. The first two scenarios are largely studied and supported, yet few studies focused on the evolution from pseudogenized protein-coding sequence to lincRNA. Due to the non-mutually exclusive nature of these three scenarios and the need of systematic investigation of lincRNA origination, we conducted a comparative genomics study to investigate the evolution of human lincRNAs.

Results

Combining with syntenic analysis

SUBMITTER: Liu WH 

PROVIDER: S-EPMC5644071 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature