Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties.

ABSTRACT:

Background

Autoreactive Th1 and Th17 cells are believed to mediate the pathology of multiple sclerosis in the central nervous system (CNS). Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of the neuroinflammation. Previously, we have shown that only Th1 but not Th17 effectors activate microglia. However, it is not clear which cells are targets of Th17 effectors in the CNS.

Methods

To understand the effects driven by Th17 cells in the CNS, we induced experimental autoimmune encephalomyelitis in wild-type mice and CD4⁺ T cell-specific integrin α4-deficient mice where trafficking of Th1 cells into the CNS was affected. We compared microglial and astrocyte response in the brain and spinal cord of these mice. We further treated

SUBMITTER: Prajeeth CK 

PROVIDER: S-EPMC5644084 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature