Generalized disequilibrium test for association in qualitative traits incorporating imprinting effects based on extended pedigrees.

ABSTRACT:

Background

For dichotomous traits, the generalized disequilibrium test with the moment estimate of the variance (GDT-ME) is a powerful family-based association method. Genomic imprinting is an important epigenetic phenomenon and currently, there has been increasing interest of incorporating imprinting to improve the test power of association analysis. However, GDT-ME does not take imprinting effects into account, and it has not been investigated whether it can be used for association analysis when the effects indeed exist.

Results

In this article, based on a novel decomposition of the genotype score according to the paternal or maternal source of the allele, we propose the generalized disequilibrium test with imprinting (GDTI) for complete pedigrees without any missing genot

SUBMITTER: Li JL 

PROVIDER: S-EPMC5644153 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature