Physiological characterization of secondary metabolite producing Penicillium cell factories.

ABSTRACT: BACKGROUND:Penicillium species are important producers of bioactive secondary metabolites. However, the immense diversity of the fungal kingdom is only scarcely represented in industrial bioprocesses and the upscaling of compound production remains a costly and labor intensive challenge. In order to facilitate the development of novel secondary metabolite producing processes, two routes are typically explored: optimization of the native producer or transferring the enzymatic pathway into a heterologous host. Recent genome sequencing of ten Penicillium species showed the vast amount of secondary metabolite gene clusters present in their genomes, and makes them accessible for rational strain improvement. In this study, we aimed to characterize the potential of these ten Penicillium species a

SUBMITTER: Grijseels S 

PROVIDER: S-EPMC5644182 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature