ASXL gain-of-function truncation mutants: defective and dysregulated forms of a natural ribosomal frameshifting product?

ABSTRACT:

Background

Programmed ribosomal frameshifting (PRF) is a gene expression mechanism which enables the translation of two N-terminally coincident, C-terminally distinct protein products from a single mRNA. Many viruses utilize PRF to control or regulate gene expression, but very few phylogenetically conserved examples are known in vertebrate genes. Additional sex combs-like (ASXL) genes 1 and 2 encode important epigenetic and transcriptional regulatory proteins that control the expression of homeotic genes during key developmental stages. Here we describe an ~150-codon overlapping ORF (termed TF) in ASXL1 and ASXL2 that, with few exceptions, is conserved throughout vertebrates.

Results

Conservation of the TF ORF, strong suppression of synonymous site variation in the overlap r

SUBMITTER: Dinan AM 

PROVIDER: S-EPMC5644247 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature