Novel oxytocin receptor variants in laboring women requiring high doses of oxytocin.

ABSTRACT:

Background

Although oxytocin commonly is used to augment or induce labor, it is difficult to predict its effectiveness because oxytocin dose requirements vary significantly among women. One possibility is that women requiring high or low doses of oxytocin have variations in the oxytocin receptor gene.

Objectives

To identify oxytocin receptor gene variants in laboring women with low and high oxytocin dosage requirements.

Study design

Term, nulliparous women requiring oxytocin doses of ≤4 mU/min (low-dose-requiring, n = 83) or ≥20 mU/min (high-dose-requiring, n = 104) for labor augmentation or induction provided consent to a postpartum blood draw as a source of genomic DNA. Targeted-amplicon sequencing (coverage >30×) with MiSeq (Illumina) was performed to discover vari

SUBMITTER: Reinl EL 

PROVIDER: S-EPMC5644384 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature