A targeted immunomic approach identifies diagnostic antigens in the human pathogen Babesia microti.

ABSTRACT:

Background

Babesia microti is a protozoan parasite responsible for the majority of reported cases of human babesiosis and a major risk to the blood supply. Laboratory screening of blood donors may help prevent transfusion-transmitted babesiosis but there is no Food and Drug Administration-approved screening method yet available. Development of a sensitive, specific, and highly automated B. microti antibody assay for diagnosis of acute babesiosis and blood screening could have an important impact on decreasing the health burden of B. microti infection.

Study design and methods

Herein, we take advantage of recent advances in B. microti genomic analyses, field surveys of the reservoir host, and human studies in endemic areas to apply a targeted immunomic approach to the discove

SUBMITTER: Cornillot E 

PROVIDER: S-EPMC5644385 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature