Randomized open-label trial of dextromethorphan in Rett syndrome.

ABSTRACT:

Objective

To determine safety and perform a preliminary assessment of dose-dependent efficacy of dextromethorphan in normalizing electrographic spikes, clinical seizures, and behavioral and cognitive functions in girls with Rett syndrome.

Methods

We used a prospective randomized, open-label trial in fast metabolizers of dextromethorphan to examine the effect of dextromethorphan on core clinical features of Rett syndrome. Interictal spike activity and clinical seizures were determined using EEG and parent reporting. Cognitive data were obtained using the Mullen Scales of Early Learning and Vineland Adaptive Behavior Scales, while behavioral data were obtained from parent-completed checklists, the Aberrant Behavior Checklist-Community Version, and the Screen for Social Interac

SUBMITTER: Smith-Hicks CL 

PROVIDER: S-EPMC5644464 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature