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Prolonged febrile illness due to CTX-M-15 extended-spectrum ?-lactamase-producing Klebsiella pneumoniae infection in Nigeria.

ABSTRACT: We report on an 8-year-old patient with septicaemia unresponsive to therapy for five weeks. Undetected, extended-spectrum ?-lactamase (ESBL) production by the infecting Klebsiella strain was regarded as responsible for treatment failure. Intravenously administered imipenem during the sixth week led to sustained resolution of fever. Resource-limited hospitals can incur prohibitive costs from ESBL-producer infections because of diagnostic limitations and consequent treatment failure involving prolonged supportive therapy.

SUBMITTER: Aboderin OA 

PROVIDER: S-EPMC5644516 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Prolonged febrile illness due to CTX-M-15 extended-spectrum β-lactamase-producing <i>Klebsiella pneumoniae</i> infection in Nigeria.

Aboderin Oladipo A OA   Adefehinti Olufemi O   Odetoyin Babatunde W BW   Olotu Amadin A AA   Okeke Iruka N IN   Adeodu Olugbenga O OO  

African journal of laboratory medicine 20120604 1

We report on an 8-year-old patient with septicaemia unresponsive to therapy for five weeks. Undetected, extended-spectrum β-lactamase (ESBL) production by the infecting <i>Klebsiella</i> strain was regarded as responsible for treatment failure. Intravenously administered imipenem during the sixth week led to sustained resolution of fever. Resource-limited hospitals can incur prohibitive costs from ESBL-producer infections because of diagnostic limitations and consequent treatment failure involvi  ...[more]

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