Epithelial-Cell-Derived Phospholipase A₂ Group 1B Is an Endogenous Anthelmintic.

ABSTRACT: Immunity to intestinal helminth infections has been well studied, but the mechanism of helminth killing prior to expulsion remains unclear. Here we identify epithelial-cell-derived phospholipase A₂ group 1B (PLA₂g1B) as a host-derived endogenous anthelmintic. PLA₂g1B is elevated in resistant mice and is responsible for killing tissue-embedded larvae. Despite comparable activities of other essential type-2-dependent immune mechanisms, Pla2g1b^-/- mice failed to expel the intestinal helminths Heligmosomoides polygyrus or Nippostrongylus brasiliensis. Expression of Pla2g1b by epithelial cells was dependent upon intestinal microbiota, adaptive immunity, and common-gamma chain-dependent signaling. Notably, Pla2g1b was downregulated in susceptible mice

SUBMITTER: Entwistle LJ 

PROVIDER: S-EPMC5644720 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature