Cord Blood Metabolome Is Highly Associated with Birth Weight, but Less Predictive for Later Weight Development.

ABSTRACT:

Background/aims

Fetal metabolism may be changed by the exposure to maternal factors, and the route to obesity may already set in utero. Cord blood metabolites might predict growth patterns and later obesity. We aimed to characterize associations of cord blood with birth weight, postnatal weight gain, and BMI in adolescence.

Methods

Over 700 cord blood samples were collected from infants participating in the German birth cohort study LISAplus. Glycerophospholipid fatty acids (GPL-FA), polar lipids, non-esterified fatty acids (NEFA), and amino acids were analyzed with a targeted, liquid chromatography-tandem mass spectrometry based metabolomics platform. Cord blood metabolites were related to growth factors by linear regression models adjusted for confounding variables.

Res

SUBMITTER: Hellmuth C 

PROVIDER: S-EPMC5644937 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature