Cerebral mGluR5 availability contributes to elevated sleep need and behavioral adjustment after sleep deprivation.

ABSTRACT: Increased sleep time and intensity quantified as low-frequency brain electrical activity after sleep loss demonstrate that sleep need is homeostatically regulated, yet the underlying molecular mechanisms remain elusive. We here demonstrate that metabotropic glutamate receptors of subtype 5 (mGluR5) contribute to the molecular machinery governing sleep-wake homeostasis. Using positron emission tomography, magnetic resonance spectroscopy, and electroencephalography in humans, we find that increased mGluR5 availability after sleep loss tightly correlates with behavioral and electroencephalographic biomarkers of elevated sleep need. These changes are associated with altered cortical myo-inositol and glycine levels, suggesting sleep loss-induced modifications downstream of mGluR5 signaling. Kno

SUBMITTER: Holst SC 

PROVIDER: S-EPMC5644949 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature