Gadolinium-Loaded Viral Capsids as Magnetic Resonance Imaging Contrast Agents.

ABSTRACT: Polymeric nanohybrid P22 virus capsids were used as templates for high density Gd³⁺ loading to explore magnetic field-dependent (0.5-7.0 T) proton relaxivity. The field-dependence of relaxivity by the spatially constrained Gd³⁺ in the capsids was similar when either the loading of the capsids or the concentration of capsids was varied. The ionic longitudinal relaxivity, r₁, decreased from 25-32 mM^-1 s^-1 at 0.5 T to 6-10 mM^-1 s^-1 at 7 T. The ionic transverse relaxivity, r₂, increased from 28-37 mM^-1 s^-1 at 0.5 T to 39-50 mM^-1 s^-1 at 7 T. The r₂/r₁ ratio increased linearly with increasing magnetic field from abou

SUBMITTER: Usselman RJ 

PROVIDER: S-EPMC5645056 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature