Multisite Experience of the Safety, Detection Rate and Diagnostic Performance of Fluciclovine (¹⁸F) Positron Emission Tomography/Computerized Tomography Imaging in the Staging of Biochemically Recurrent Prostate Cancer.

ABSTRACT:

Purpose

Sensitive detection of cancer foci in men experiencing biochemical recurrence following initial treatment of prostate cancer is of great clinical significance with a possible impact on subsequent treatment choice. We describe a multisite experience of the efficacy and safety of the positron emission tomography/computerized tomography agent fluciclovine (¹⁸F) after biochemical recurrence.

Materials and methods

A total of 596 patients underwent fluciclovine (¹⁸F) positron emission tomography/computerized tomography at 4 clinical sites. Detection rate determinations were stratified by the baseline prostate specific antigen value. Diagnostic performance was assessed against a histological reference standard in 143 scans.

Results

The subject l

SUBMITTER: Bach-Gansmo T 

PROVIDER: S-EPMC5645081 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature