Advanced maternal age and adverse pregnancy outcomes: A systematic review and meta-analysis.

ABSTRACT:

Background

Advanced maternal age (AMA; ≥35 years) is an increasing trend and is reported to be associated with various pregnancy complications.

Objective

To determine the risk of stillbirth and other adverse pregnancy outcomes in women of AMA.

Search strategy

Embase, Medline (Ovid), Cochrane Database of Systematic Reviews, ClinicalTrials.gov, LILACS and conference proceedings were searched from ≥2000.

Selection criteria

Cohort and case-control studies reporting data on one or more co-primary outcomes (stillbirth or fetal growth restriction (FGR)) and/or secondary outcomes in mothers ≥35 years and <35 years.

Data collection and analysis

The effect of age on pregnancy outcome was investigated by random effects meta-analysis and meta-regression. Stillbirth

SUBMITTER: Lean SC 

PROVIDER: S-EPMC5645107 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature