Worsening calcification propensity precedes all-cause and cardiovascular mortality in haemodialyzed patients.

ABSTRACT: A novel in-vitro test (T₅₀-test) assesses ex-vivo serum calcification propensity which predicts mortality in HD patients. The association of longitudinal changes of T₅₀ with all-cause and cardiovascular mortality has not been investigated. We assessed T₅₀ in paired sera collected at baseline and at 24 months in 188 prevalent European HD patients from the ISAR cohort, most of whom were Caucasians. Patients were followed for another 19 [interquartile range: 11-37] months. Serum T₅₀ exhibited a significant decline between baseline and 24 months (246 ± 64 to 190 ± 68 minutes; p < 0.001). With serum Δ-phosphate showing the strongest independent association with declining T₅₀ (r = -0.39; p < 0.001) in multivariable linear regression. The rat

SUBMITTER: Lorenz G 

PROVIDER: S-EPMC5645333 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature