Dynamic and Modularized MicroRNA Regulation and Its Implication in Human Cancers.

ABSTRACT: MicroRNA is responsible for the fine-tuning of fundamental cellular activities and human disease development. The altered availability of microRNAs, target mRNAs, and other types of endogenous RNAs competing for microRNA interactions reflects the dynamic and conditional property of microRNA-mediated gene regulation that remains under-investigated. Here we propose a new integrative method to study this dynamic process by considering both competing and cooperative mechanisms and identifying functional modules where different microRNAs co-regulate the same functional process. Specifically, a new pipeline was built based on a meta-Lasso regression model and the proof-of-concept study was performed using a large-scale genomic dataset from ~4,200 patients with 9 cancer types. In the analysis, 10

SUBMITTER: Shu J 

PROVIDER: S-EPMC5645395 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature