Role of regulatory T cells in acute myeloid leukemia patients undergoing relapse-preventive immunotherapy.

ABSTRACT: Regulatory T cells (T_regs) have been proposed to dampen functions of anti-neoplastic immune cells and thus promote cancer progression. In a phase IV trial (Re:Mission Trial, NCT01347996, http://www.clinicaltrials.gov ) 84 patients (age 18-79) with acute myeloid leukemia (AML) in first complete remission (CR) received ten consecutive 3-week cycles of immunotherapy with histamine dihydrochloride (HDC) and low-dose interleukin-2 (IL-2) to prevent relapse of leukemia in the post-consolidation phase. This study aimed at defining the features, function and dynamics of Foxp3⁺CD25^highCD4⁺ T_regs during immunotherapy and to determine the potential impact of T_regs on relapse risk and survival. We observed a pronounced increase in T

SUBMITTER: Sander FE 

PROVIDER: S-EPMC5645432 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature