Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features.

ABSTRACT:

Aim

To investigate the association between 16 insertion-deletions (INDEL) polymorphisms, colorectal cancer (CRC) risk and clinical features in an admixed population.

Methods

One hundred and forty patients with CRC and 140 cancer-free subjects were examined. Genomic DNA was extracted from peripheral blood samples. Polymorphisms and genomic ancestry distribution were assayed by Multiplex-PCR reaction, separated by capillary electrophoresis on the ABI 3130 Genetic Analyzer instrument and analyzed on GeneMapper ID v3.2. Clinicopathological data were obtained by consulting the patients' clinical charts, intra-operative documentation, and pathology scoring.

Results

Logistic regression analysis showed that polymorphism variations in IL4 gene was associated with increa

SUBMITTER: Marques D 

PROVIDER: S-EPMC5645618 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature