Rhodium-catalyzed C-H functionalization-based approach to eight-membered lactams.

ABSTRACT: A Rh(iii) catalyzed formal [4 + 2 + 2] cyclization of N-pivaloyloxybenzamides 1 with 1,6-allene-enes 2 by C-H functionalization is reported. The reactions occur at room temperature and are compatible with air and moisture with a tolerance of many synthetically useful functional groups. The follow-up modifications of the products have been demonstrated. After careful mechanistic studies and DFT calculation, a reaction mechanism was proposed.

SUBMITTER: Wu S 

PROVIDER: S-EPMC5645731 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature