Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease.

ABSTRACT:

Background

Alcohol abuse has deleterious effects on human health by disrupting the functions of many organs and systems. Gut microbiota has been implicated in the pathogenesis of alcohol-related liver diseases, with its composition manifesting expressed dysbiosis in patients suffering from alcoholic dependence. Due to its inherent plasticity, gut microbiota is an important target for prevention and treatment of these diseases. Identification of the impact of alcohol abuse with associated psychiatric symptoms on the gut community structure is confounded by the liver dysfunction. In order to differentiate the effects of these two factors, we conducted a comparative "shotgun" metagenomic survey of 99 patients with the alcohol dependence syndrome represented by two cohorts-with and wit

SUBMITTER: Dubinkina VB 

PROVIDER: S-EPMC5645934 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature