Differential expression of porcine microRNAs in African swine fever virus infected pigs: a proof-of-concept study.

ABSTRACT:

Background

African swine fever (ASF) is a re-expanding devastating viral disease currently threatening the pig industry worldwide. MicroRNAs are a class of 17-25 nucleotide non- coding RNAs that have been shown to have critical functions in a wide variety of biological processes, such as cell differentiation, cell cycle regulation, carcinogenesis, apoptosis, regulation of immunity as well as in viral infections by cleavage or translational repression of mRNAs. Nevertheless, there is no information about miRNA expression in an ASFV infection.

Methods

In this proof-of-concept study, we have analyzed miRNAs expressed in spleen and submandibular lymph node of experimentally infected pigs with a virulent (E75) or its derived attenuated (E75CV1) ASFV strain, as well as, at differe

SUBMITTER: Nunez-Hernandez F 

PROVIDER: S-EPMC5646143 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature