A double-blind randomized trial of fish oil to lower triglycerides and improve cardiometabolic risk in adolescents.

ABSTRACT:

Objectives

To determine the efficacy of 4 g/day fish oil to lower triglycerides and impact lipoprotein particles, inflammation, insulin resistance, coagulation, and thrombosis.

Study design

Participants (n = 42, age 14 ± 2 years) with hypertriglyceridemia and low-density lipoprotein (LDL) cholesterol <160 mg/dL were enrolled in a randomized, double-blind, crossover trial comparing 4 g of fish oil daily with placebo. Treatment interval was 8 weeks with a 4-week washout. Lipid profile, lipoprotein particle distribution and size, glucose, insulin, high-sensitivity C-reactive protein, interleukin-6, fibrinogen, plasminogen activator inhibitor-1, and thrombin generation were measured.

Results

Baseline lipid profile was total cholesterol 194 (5.4) mg/dL (mean [SE]), triglyc

SUBMITTER: Gidding SS 

PROVIDER: S-EPMC5646219 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature