Copper Chaperone CupA and Zinc Control CopY Regulation of the Pneumococcal cop Operon.

ABSTRACT: Any metal in excess can be toxic; therefore, metal homeostasis is critical to bacterial survival. Bacteria have developed specialized metal import and export systems for this purpose. For broadly toxic metals such as copper, bacteria have evolved only export systems. The copper export system (cop operon) usually consists of the operon repressor, the copper chaperone, and the copper exporter. In Streptococcus pneumoniae, the causative agent of pneumonia, otitis media, sepsis, and meningitis, little is known about operon regulation. This is partly due to the S. pneumoniae repressor, CopY, and copper chaperone, CupA, sharing limited homology to proteins of putative related function and confirmed established systems. In this study, we examined CopY metal crosstalk, CopY in

SUBMITTER: Neubert MJ 

PROVIDER: S-EPMC5646241 | biostudies-literature | 2017 Sep-Oct

REPOSITORIES: biostudies-literature