Impact of Dietary Resistant Starch on the Human Gut Microbiome, Metaproteome, and Metabolome.

ABSTRACT: Diet can influence the composition of the human microbiome, and yet relatively few dietary ingredients have been systematically investigated with respect to their impact on the functional potential of the microbiome. Dietary resistant starch (RS) has been shown to have health benefits, but we lack a mechanistic understanding of the metabolic processes that occur in the gut during digestion of RS. Here, we collected samples during a dietary crossover study with diets containing large or small amounts of RS. We determined the impact of RS on the gut microbiome and metabolic pathways in the gut, using a combination of "omics" approaches, including 16S rRNA gene sequencing, metaproteomics, and metabolomics. This multiomics approach captured changes in the abundance of specific bacterial specie

SUBMITTER: Maier TV 

PROVIDER: S-EPMC5646248 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature