Ontology highlight
ABSTRACT:
SUBMITTER: Wapinski OL
PROVIDER: S-EPMC5646379 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Cell reports 20170901 13
How transcription factors (TFs) reprogram one cell lineage to another remains unclear. Here, we define chromatin accessibility changes induced by the proneural TF Ascl1 throughout conversion of fibroblasts into induced neuronal (iN) cells. Thousands of genomic loci are affected as early as 12 hr after Ascl1 induction. Surprisingly, over 80% of the accessibility changes occur between days 2 and 5 of the 3-week reprogramming process. This chromatin switch coincides with robust activation of endoge ...[more]