Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites.

ABSTRACT: Tissue-resident memory T cells (TRMs) in mice mediate optimal protective immunity to infection and vaccination, while in humans, the existence and properties of TRMs remain unclear. Here, we use a unique human tissue resource to determine whether human tissue memory T cells constitute a distinct subset in diverse mucosal and lymphoid tissues. We identify a core transcriptional profile within the CD69⁺ subset of memory CD4⁺ and CD8⁺ T cells in lung and spleen that is distinct from that of CD69^- TEM cells in tissues and circulation and defines human TRMs based on homology to the transcriptional profile of mouse CD8⁺ TRMs. Human TRMs in diverse sites exhibit increased expression of adhesion and inhibitory molecules, produce both pro-infla

SUBMITTER: Kumar BV 

PROVIDER: S-EPMC5646692 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature