The biocompatibility studies of polymer dots on pregnant mice and fetuses.

ABSTRACT: Semiconducting polymer dots (Pdots) are small nanoparticles consisting primarily of fluorescent pi-conjugated polymers which show superior optical properties for biological imaging and biosensors. It is necessary to explore systematically the toxicity of Pdots on animals before extensive biomedical applications. The reproductive system is very sensitive to the external invasion and essential for species reproduction as well. In this work, we used the pregnant mice to investigate the reproductive toxicity of Pdots. The changes in body weight of each maternal mouse were recorded every two days. The main organs were collected and analyzed as soon as all the pregnant mice were sacrificed on the 15^th embryonic day. Distributions of Pdots on maternal major organs and tissues were exam

SUBMITTER: Wu N 

PROVIDER: S-EPMC5646735 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature