Identification of pivotal genes and pathways for spinal cord injury via bioinformatics analysis.

ABSTRACT: The present study aimed to identify key genes and pathways associated with spinal cord injury (SCI) and subsequently investigate possible therapeutic targets for the condition. The array data of GSE20907 was downloaded from the Gene Expression Omnibus database and 24 gene chips, including 3‑day, 4‑day, 1‑week, 2‑week and 1‑month post‑SCI together with control propriospinal neurons, were used for the analysis. The raw data was normalized and then the differentially expressed genes (DEGs) in the (A) 2‑week post‑SCI group vs. control group, (B) 1‑month post‑SCI group vs. control group, (C) 1‑month and 2‑week post‑SCI group vs. control group, and (D) all post‑SCI groups vs. all control groups, were analyzed with a limma package. Gene Ontology annotation and Kyoto Encyclopedia of Genes and Geno

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC5646972 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature