Comparative proteomic analysis of rats subjected to water immersion and restraint stress as an insight into gastric ulcers.

ABSTRACT: In the present study, comparative proteomic analysis was performed in rats subjected to water immersion‑restraint stress (WRS). A total of 26 proteins were differentially expressed and identified using matrix‑assisted laser desorption/ionization time of flight mass spectrometry. Among the 26 differentially expressed protein spots identified, 13 proteins were significantly upregulated under WRS, including pyruvate kinase and calreticulin, which may be closely associated with energy metabolism. In addition, 12 proteins were downregulated under WRS, including hemoglobin subunit β‑2 and keratin type II cytoskeletal 8, which may be important in protein metabolism and cell death. Gene Ontology analysis revealed the cellular distribution, molecular function and biological processes of the identif

SUBMITTER: Zhou ZR 

PROVIDER: S-EPMC5647087 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature