Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain.

ABSTRACT: Elevated iron and decreased copper levels are cardinal features of the degenerating substantia nigra pars compacta in the Parkinson's disease brain. Both of these redox-active metals, and fellow transition metals manganese and zinc, are found at high concentrations within the midbrain and participate in a range of unique biological reactions. We examined the total metal content and cellular compartmentalisation of manganese, iron, copper and zinc in the degenerating substantia nigra, disease-affected but non-degenerating fusiform gyrus, and unaffected occipital cortex in the post mortem Parkinson's disease brain compared with age-matched controls. An expected increase in iron and a decrease in copper concentration was isolated to the soluble cellular fraction, encompassing both interstitia

SUBMITTER: Genoud S 

PROVIDER: S-EPMC5647261 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature