Heparin-binding protein (HBP) improves prediction of sepsis-related acute kidney injury.

ABSTRACT:

Background

Sepsis-related acute kidney injury (AKI) accounts for major morbidity and mortality among the critically ill. Heparin-binding protein (HBP) is a promising biomarker in predicting development and prognosis of severe sepsis and septic shock that has recently been proposed to be involved in the pathophysiology of AKI. The objective of this study was to investigate the added predictive value of measuring plasma HBP on admission to the intensive care unit (ICU) regarding the development of septic AKI.

Methods

We included 601 patients with severe sepsis or septic shock from the prospective, observational FINNAKI study conducted in seventeen Finnish ICUs during a 5-month period (1 September 2011-1 February 2012). The main outcome measure was the development of KDIGO AKI

SUBMITTER: Tverring J 

PROVIDER: S-EPMC5647316 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature