Task demands, tDCS intensity, and the COMT val¹⁵⁸met polymorphism impact tDCS-linked working memory training gains.

ABSTRACT: Working memory (WM) training paired with transcranial direct current stimulation (tDCS) can improve executive function in older adults. The unclear mechanism of tDCS likely depends on tDCS intensity, and task relevant genetic factors (e.g., for WM: COMT val¹⁵⁸met, DAT, BDNF val⁶⁶met). Higher tDCS intensity does not always lead to greater cognitive gains, and genetic polymorphisms may modulate tDCS-linked WM improvements. To evaluate these factors, 137 healthy older adults provided DNA samples and received Visual and Spatial WM training paired with tDCS (sham, 1, 1.5, 2 mA). After one session of tDCS, significant group differences in WM performance were predicted by COMT val¹⁵⁸met status. One month after training, there was a significant interaction of tDCS

SUBMITTER: Stephens JA 

PROVIDER: S-EPMC5647397 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature