Closed-Loop Control Without Meal Announcement in Type 1 Diabetes.

ABSTRACT:

Objective

A fully closed-loop insulin-only system was developed to provide glucose control in patients with type 1 diabetes without requiring announcement of meals or activity. Our goal was to assess initial safety and efficacy of this system.

Research design and methods

The multiple model probabilistic controller (MMPPC) anticipates meals when the patient is awake. The controller used the subject's basal rates and total daily insulin dose for initialization. The system was tested at two sites on 10 patients in a 30-h inpatient study, followed by 15 subjects at three sites in a 54-h supervised hotel study, where the controller was challenged by exercise and unannounced meals. The system was implemented on the UVA DiAs system using a Roche Spirit Combo Insulin Pump and a Dexc

SUBMITTER: Cameron FM 

PROVIDER: S-EPMC5647490 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature