Intranasal Oxytocin Selectively Modulates Large-Scale Brain Networks in Humans.

ABSTRACT: A growing body of evidence indicates that the neuropeptide oxytocin (OT) alters the neural correlates of socioemotional and salience processing. Yet the effects of OT over important large-scale networks involved in these processes, such as the default mode (DM), ventral attention (VA), and cingulo-opercular (CO) networks, remain unknown. Therefore, we conducted a placebo-controlled crossover study with intranasal 24 IU OT in 38 healthy male subjects using a resting-state functional magnetic resonance imaging paradigm to investigate its impact over these three networks candidates. To understand the underlying mechanisms of the neuropeptide, we compared the intranetwork connectivity for each network candidate and also the internetwork connectivity across all networks between both treatment c

SUBMITTER: Brodmann K 

PROVIDER: S-EPMC5647506 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature