How Many Protein Sequences Fold to a Given Structure? A Coevolutionary Analysis.

ABSTRACT: Quantifying the relationship between protein sequence and structure is key to understanding the protein universe. A fundamental measure of this relationship is the total number of amino acid sequences that can fold to a target protein structure, known as the "sequence capacity," which has been suggested as a proxy for how designable a given protein fold is. Although sequence capacity has been extensively studied using lattice models and theory, numerical estimates for real protein structures are currently lacking. In this work, we have quantitatively estimated the sequence capacity of 10 proteins with a variety of different structures using a statistical model based on residue-residue co-evolution to capture the variation of sequences from the same protein family. Remarkably, we find that

SUBMITTER: Tian P 

PROVIDER: S-EPMC5647607 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature