A Review of the Genetics of Hypertension with a Focus on Gene-Environment Interactions.

ABSTRACT:

Purpose of review

Here, we discuss the interpretation and modeling of gene-environment interactions in hypertension-related phenotypes, with a focus on the necessary assumptions and possible challenges.

Recent findings

Recently, small cohort studies have discovered several novel genetic variants associated with hypertension-related phenotypes through modeling gene-environment interactions. Several consortia-based meta-analytic efforts have uncovered many novel genetic variants in hypertension without modeling interaction terms, giving promise to future meta-analytic efforts that incorporate gene-environment interactions. Heritability studies and genome-wide association studies have established that hypertension, a prevalent cardiovascular disease, has a genetic component tha

SUBMITTER: Waken RJ 

PROVIDER: S-EPMC5647656 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature