Identifying transmission routes of Streptococcus pneumoniae and sources of acquisitions in high transmission communities.

ABSTRACT: Identifying the transmission sources and reservoirs of Streptococcus pneumoniae (SP) is a long-standing question for pneumococcal epidemiology, transmission dynamics, and vaccine policy. Here we use serotype to identify SP transmission and examine acquisitions (in the same household, local community, and county, or of unidentified origin) in a longitudinal cohort of children and adults from the Navajo Nation and the White Mountain Apache American Indian Tribes. We found that adults acquire SP relatively more in the household than other age groups, and children 2-8 years old typically acquire in their own or surrounding communities. Age-specific transmission probability matrices show that transmissions within household were mostly seen from older to younger siblings. Outside the household,

SUBMITTER: Althouse BM 

PROVIDER: S-EPMC5647670 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature