Saccharin induced liver inflammation in mice by altering the gut microbiota and its metabolic functions.

ABSTRACT: Maintaining the balance of the gut microbiota and its metabolic functions is vital for human health, however, this balance can be disrupted by various external factors including food additives. A range of food and beverages are sweetened by saccharin, which is generally considered to be safe despite controversial debates. However, recent studies indicated that saccharin perturbed the gut microbiota. Inflammation is frequently associated with disruptions of the gut microbiota. The aim of this study is to investigate the relationship between host inflammation and perturbed gut microbiome by saccharin. C57BL/6J male mice were treated with saccharin in drinking water for six months. Q-PCR was used to detect inflammatory markers in mouse liver, while 16S rRNA gene sequencing and metabolomics we

SUBMITTER: Bian X 

PROVIDER: S-EPMC5647777 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature