The L-type voltage-gated calcium channel Ca_V1.2 mediates fear extinction and modulates synaptic tone in the lateral amygdala.

ABSTRACT: L-type voltage-gated calcium channels (LVGCCs) have been implicated in both the formation and the reduction of fear through Pavlovian fear conditioning and extinction. Despite the implication of LVGCCs in fear learning and extinction, studies of the individual LVGCC subtypes, Ca_V1.2 and Ca_V1.3, using transgenic mice have failed to find a role of either subtype in fear extinction. This discontinuity between the pharmacological studies of LVGCCs and the studies investigating individual subtype contributions could be due to the limited neuronal deletion pattern of the Ca_V1.2 conditional knockout mice previously studied to excitatory neurons in the forebrain. To investigate the effects of deletion of Ca_V1.2 in all neuronal populations, we generated C

SUBMITTER: Temme SJ 

PROVIDER: S-EPMC5647931 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature