Ontology highlight
ABSTRACT:
SUBMITTER: Narayan S
PROVIDER: S-EPMC5648000 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Cell reports 20170801 7
SOX2 and OCT4, in conjunction with KLF4 and cMYC, are sufficient to reprogram human fibroblasts to induced pluripotent stem cells (iPSCs), but it is unclear if they function as transcriptional activators or as repressors. We now show that, like OCT4, SOX2 functions as a transcriptional activator. We substituted SOX2-VP16 (a strong activator) for wild-type (WT) SOX2, and we saw an increase in the efficiency and rate of reprogramming, whereas the SOX2-HP1 fusion (a strong repressor) eliminated rep ...[more]