Nonalcoholic Steatohepatitis is Associated with Cardiac Remodeling and Dysfunction.

ABSTRACT:

Objective

Preliminary data suggest that nonalcoholic fatty liver disease is associated with early heart failure (HF). However, whether nonalcoholic steatohepatitis (NASH) is directly associated with echocardiographic changes in cardiac structure or function remains unknown.

Methods

A retrospective cohort was identified of individuals (N = 65) without known heart disease, undergoing elective bariatric surgery with perioperative liver biopsy, and available recent transthoracic echocardiography (TTE). TTE measures were evaluated by NASH status using correlation coefficients, ANOVA, and linear regression, accounting for cardiometabolic factors.

Results

Median age was 47 years; 22% (n = 14) had NASH. NASH patients had increased median left atrial (LA) volume (28.6 mL/m

SUBMITTER: Simon TG 

PROVIDER: S-EPMC5648006 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature