A Magnetic Resonance Imaging-based approach to quantify radiation-induced normal tissue injuries applied to trismus in head and neck cancer.

ABSTRACT:

Background and purpose

In this study we investigated the ability of textures from T1-weighted MRI scans post-contrast (T1w_post) to identify the critical muscle(s) for radiation-induced trismus.

Materials and methods

The study included ten cases (Trismus: ≥Grade 1), and ten age-sex-tumor-location-and-stage-matched controls treated with intensity-modulated radiotherapy to 70Gy@2.12Gy in 2005-2009. Trismus status and T1w_Post were conducted within one year post-radiotherapy. For the masseter, lateral and medial pterygoids, and temporalis (M/LP/MP/T), 24 textures were extracted (Grey Level Co-Occurrence (GLCM), Histogram, and Shape). Univariate logistic regression with Bootstrapping (1000 populations) was applied to compare the muscle me

SUBMITTER: Thor M 

PROVIDER: S-EPMC5648027 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature