Validation and recalibration of the Framingham cardiovascular disease risk models in an Australian Indigenous cohort.

ABSTRACT: Background In Australia, clinical guidelines for primary prevention of cardiovascular disease recommend the use of the Framingham model to help identify those at high risk of developing the disease. However, this model has not been validated for the Indigenous population. Design Cohort study. Methods Framingham models were applied to the Well Person's Health Check (WPHC) cohort (followed 1998-2014), which included 1448 Aboriginal and Torres Strait Islanders from remote Indigenous communities in Far North Queensland. Cardiovascular disease risk predicted by the original and recalibrated Framingham models were compared with the observed risk in the WPHC cohort. Results The observed five- and 10-year cardiovascular disease probability of the WPHC cohort was 10.0% (95% confidence interval (CI)

SUBMITTER: Hua X 

PROVIDER: S-EPMC5648047 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature