An integrative in-silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae.

ABSTRACT: Corynebacterium diphtheriae (Cd) is a Gram-positive human pathogen responsible for diphtheria infection and once regarded for high mortalities worldwide. The fatality gradually decreased with improved living standards and further alleviated when many immunization programs were introduced. However, numerous drug-resistant strains emerged recently that consequently decreased the efficacy of current therapeutics and vaccines, thereby obliging the scientific community to start investigating new therapeutic targets in pathogenic microorganisms. In this study, our contributions include the prediction of modelome of 13 C. diphtheriae strains, using the MHOLline workflow. A set of 463 conserved proteins were identified by combining the results of pangenomics based core-genome and core-modelome ana

SUBMITTER: Jamal SB 

PROVIDER: S-EPMC5648181 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature