The prevalence of human papillomavirus in oropharyngeal cancer in a New Zealand population.

ABSTRACT:

Background

The incidence of oropharyngeal cancer (OPC) in New Zealand (NZ) has more than doubled over the last 14 years with 126 cases in 2010. Overseas studies have shown that human papillomavirus (HPV) plays a significant role in the development of these cancers. However, the role of HPV in OPC and the burden on the NZ health system is unclear.

Aim

The aim of the study was to determine the prevalence and the genotypes of HPV associated with OPC in New Zealand.

Methods

In this study, 621 OPC were identified from cancer registry data from 1996-98, 2003-05, and 2010-12. Biopsies of 267 cases were then retrieved from laboratories throughout New Zealand. p16 immunohistochemistry and a human beta globin PCR were performed on all specimens. HPV genotyping was performed on

SUBMITTER: Lucas-Roxburgh R 

PROVIDER: S-EPMC5648183 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature