Upward trends of acquired drug resistances in Ethiopian HIV-1C isolates: A decade longitudinal study.

ABSTRACT:

Background

The emergence, accumulation and spread of HIV-1 drug resistance strains in Africa could compromise the effectiveness of HIV treatment programs. This study was aimed at determining the incidence of virological failure and acquired drug resistance mutations overtime and identifying the most common mutational pathways of resistance in a well characterized HIV-1C infected Ethiopian cohort.

Methods

A total of 320 patients (220 ART naïve and 100 on first lines ART) were included and followed. ART initiation and patients' monitoring was based on the WHO clinical and immunological parameters. HIV viral load measurement and genotypic drug resistance testing were done at baseline (T0-2008) and after on average at a median time of 30 months on ART at three time points (T1-20

SUBMITTER: Mulu A 

PROVIDER: S-EPMC5648217 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature